This article discusses autoimmune skin disorders in humans. If you think someone may have an autoimmune disorder, you can systematically scan their body for the following symptoms. It is best to consult with a medical professional, ideally one who is familiar with autoimmune disorders, but that is not always possible. If you’re on your own, here is a step-by-step primer for narrowing down possible autoimmune disorders that might be affecting you or the person you’re examining.
1.Look for large blisters on the skin and the oral cavity, especially in people between the ages between 40 and 60 years.. This is a major characteristic of pemphigus vulgaris. This is a chronic disease which is mediated by Immunoglobulin G antibody or IgG. Immunoglobulin G is thought to react in the skin in such a way as to break intercellular junctions of the epidermis and in particular that of keratinocytes. This leads in turn to separation of these cells from each other, a process which is called acantholysis. This in turn leads to the formation of vesicles that contain keratinocytes. There are accompanying to this disease several systemic symptoms such as fever and weight loss. This is a potentially life threatening disorder that can lead to death if left untreated. Treatment of this disorder includes the administration of drugs that suppress the action of the immune system such as steroids. If you suspect this is the disorder you are identifying, try to make sure the person receives medical attention as quickly as possible.