How is PsA an autoimmune disease?
PsA is an autoimmune disease, meaning it occurs when the immune system mistakenly attacks healthy tissue, in the case of PsA, the joints, connective tissue, and skin. The dysregulated immune response causes chronic inflammation that triggers joint pain, stiffness, and swelling. The inflammation can affect the entire body and may lead to permanent joint and tissue damage if it is not treated early and aggressively.
Autoimmune diseases often have periods when symptoms get significantly worse, or flare-ups, and periods of remission, when symptoms significantly lessen or seem to disappear. Even though you may not be experiencing a flare-up, your body can still be impacted by the chronic inflammation and you may experience other symptoms like fatigue as a result.